SNPeffect: a database mapping molecular phenotypic effects of human non-synonymous coding SNPs
Identifieur interne : 001740 ( Main/Exploration ); précédent : 001739; suivant : 001741SNPeffect: a database mapping molecular phenotypic effects of human non-synonymous coding SNPs
Auteurs : Joke Reumers ; Joost Schymkowitz ; Jesper Ferkinghoff-Borg [Danemark] ; Francois Stricher ; Luis Serrano ; Frederic RousseauSource :
- Nucleic Acids Research [ 0305-1048 ] ; 2005-01-01.
Abstract
Single nucleotide polymorphisms (SNPs) are an increasingly important tool for genetic and biomedical research. However, the accumulated sequence information on allelic variation is not matched by an understanding of the effect of SNPs on the functional attributes or ‘molecular phenotype’ of a protein. Towards this aim we developed SNPeffect, an online resource of human non-synonymous coding SNPs (nsSNPs) mapping phenotypic effects of allelic variation in human genes. SNPeffect contains 31 659 nsSNPs from 12 480 human proteins. The current release of SNPeffect incorporates data on protein stability, integrity of functional sites, protein phosphorylation and glycosylation, subcellular localization, protein turnover rates, protein aggregation, amyloidosis and chaperone interaction. The SNP entries are accessible through both a search and browse interface and are linked to most major biological databases. The data can be displayed as detailed descriptions of individual SNPs or as an overview of all SNPs for a given protein. SNPeffect will be regularly updated and can be accessed at http://snpeffect.vib.be/.
Url:
DOI: 10.1093/nar/gki086
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000811
- to stream Istex, to step Curation: 000811
- to stream Istex, to step Checkpoint: 001172
- to stream Main, to step Merge: 001749
- to stream Main, to step Curation: 001740
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">SNPeffect: a database mapping molecular phenotypic effects of human non-synonymous coding SNPs</title><author><name sortKey="Reumers, Joke" sort="Reumers, Joke" uniqKey="Reumers J" first="Joke" last="Reumers">Joke Reumers</name></author><author><name sortKey="Schymkowitz, Joost" sort="Schymkowitz, Joost" uniqKey="Schymkowitz J" first="Joost" last="Schymkowitz">Joost Schymkowitz</name></author><author><name sortKey="Ferkinghoff Borg, Jesper" sort="Ferkinghoff Borg, Jesper" uniqKey="Ferkinghoff Borg J" first="Jesper" last="Ferkinghoff-Borg">Jesper Ferkinghoff-Borg</name></author><author><name sortKey="Stricher, Francois" sort="Stricher, Francois" uniqKey="Stricher F" first="Francois" last="Stricher">Francois Stricher</name></author><author><name sortKey="Serrano, Luis" sort="Serrano, Luis" uniqKey="Serrano L" first="Luis" last="Serrano">Luis Serrano</name></author><author><name sortKey="Rousseau, Frederic" sort="Rousseau, Frederic" uniqKey="Rousseau F" first="Frederic" last="Rousseau">Frederic Rousseau</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:44853CCFFFAD66672FE0ACFE427C3C74CC86ADE9</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1093/nar/gki086</idno><idno type="url">https://api.istex.fr/document/44853CCFFFAD66672FE0ACFE427C3C74CC86ADE9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000811</idno><idno type="wicri:Area/Istex/Curation">000811</idno><idno type="wicri:Area/Istex/Checkpoint">001172</idno><idno type="wicri:doubleKey">0305-1048:2005:Reumers J:snpeffect:a:database</idno><idno type="wicri:Area/Main/Merge">001749</idno><idno type="wicri:Area/Main/Curation">001740</idno><idno type="wicri:Area/Main/Exploration">001740</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">SNPeffect: a database mapping molecular phenotypic effects of human non-synonymous coding SNPs</title><author><name sortKey="Reumers, Joke" sort="Reumers, Joke" uniqKey="Reumers J" first="Joke" last="Reumers">Joke Reumers</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Schymkowitz, Joost" sort="Schymkowitz, Joost" uniqKey="Schymkowitz J" first="Joost" last="Schymkowitz">Joost Schymkowitz</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ferkinghoff Borg, Jesper" sort="Ferkinghoff Borg, Jesper" uniqKey="Ferkinghoff Borg J" first="Jesper" last="Ferkinghoff-Borg">Jesper Ferkinghoff-Borg</name><affiliation wicri:level="1"><country xml:lang="fr">Danemark</country><wicri:regionArea>Niels Bohr Institute, Blegdamsvej 17, Copenhagen, DK-2100</wicri:regionArea><wicri:noRegion>DK-2100</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Stricher, Francois" sort="Stricher, Francois" uniqKey="Stricher F" first="Francois" last="Stricher">Francois Stricher</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Serrano, Luis" sort="Serrano, Luis" uniqKey="Serrano L" first="Luis" last="Serrano">Luis Serrano</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rousseau, Frederic" sort="Rousseau, Frederic" uniqKey="Rousseau F" first="Frederic" last="Rousseau">Frederic Rousseau</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Nucleic Acids Research</title><title level="j" type="abbrev">Nucl. Acids Res.</title><idno type="ISSN">0305-1048</idno><idno type="eISSN">1362-4962</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2005-01-01">2005-01-01</date><biblScope unit="volume">33</biblScope><biblScope unit="supplement">suppl_1</biblScope><biblScope unit="page" from="D527">D527</biblScope><biblScope unit="page" to="D532">D532</biblScope></imprint><idno type="ISSN">0305-1048</idno></series><idno type="istex">44853CCFFFAD66672FE0ACFE427C3C74CC86ADE9</idno><idno type="DOI">10.1093/nar/gki086</idno><idno type="local">gki086</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1048</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Single nucleotide polymorphisms (SNPs) are an increasingly important tool for genetic and biomedical research. However, the accumulated sequence information on allelic variation is not matched by an understanding of the effect of SNPs on the functional attributes or ‘molecular phenotype’ of a protein. Towards this aim we developed SNPeffect, an online resource of human non-synonymous coding SNPs (nsSNPs) mapping phenotypic effects of allelic variation in human genes. SNPeffect contains 31 659 nsSNPs from 12 480 human proteins. The current release of SNPeffect incorporates data on protein stability, integrity of functional sites, protein phosphorylation and glycosylation, subcellular localization, protein turnover rates, protein aggregation, amyloidosis and chaperone interaction. The SNP entries are accessible through both a search and browse interface and are linked to most major biological databases. The data can be displayed as detailed descriptions of individual SNPs or as an overview of all SNPs for a given protein. SNPeffect will be regularly updated and can be accessed at http://snpeffect.vib.be/.</div></front></TEI><affiliations><list><country><li>Danemark</li></country></list><tree><noCountry><name sortKey="Reumers, Joke" sort="Reumers, Joke" uniqKey="Reumers J" first="Joke" last="Reumers">Joke Reumers</name><name sortKey="Rousseau, Frederic" sort="Rousseau, Frederic" uniqKey="Rousseau F" first="Frederic" last="Rousseau">Frederic Rousseau</name><name sortKey="Schymkowitz, Joost" sort="Schymkowitz, Joost" uniqKey="Schymkowitz J" first="Joost" last="Schymkowitz">Joost Schymkowitz</name><name sortKey="Serrano, Luis" sort="Serrano, Luis" uniqKey="Serrano L" first="Luis" last="Serrano">Luis Serrano</name><name sortKey="Stricher, Francois" sort="Stricher, Francois" uniqKey="Stricher F" first="Francois" last="Stricher">Francois Stricher</name></noCountry><country name="Danemark"><noRegion><name sortKey="Ferkinghoff Borg, Jesper" sort="Ferkinghoff Borg, Jesper" uniqKey="Ferkinghoff Borg J" first="Jesper" last="Ferkinghoff-Borg">Jesper Ferkinghoff-Borg</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001740 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001740 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:44853CCFFFAD66672FE0ACFE427C3C74CC86ADE9
|texte= SNPeffect: a database mapping molecular phenotypic effects of human non-synonymous coding SNPs
}}
| This area was generated with Dilib version V0.6.25. |  |